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The preparation of deuterated solvents can be complex and often involves isotopic labeling, which is a specialized field in itself. Chemists can either synthesize deuterated compounds directly or purchase commercially available deuterated solvents. The cost of deuterated solvents tends to be higher than their protonated counterparts, primarily due to the intricate processes required for their preparation. However, the advantages they offer in terms of the quality of data obtained justify this expense for researchers.